Eric Clapton has announced the return of Crossroads Guitar Festival, set to take place at Arena in Los Angeles on September 23rd–24th.

The 6th edition of Crossroads Guitar Festival will feature some of the world’s best guitarists, with Clapton performing both nights, alongside other artists such as Gary Clark Jr., Sheryl Crow, Santana, Jakob Dylan, Albert Lee, Los Lobos, Stephen Stills, Taj Mahal, ZZ Top, the John Mayer Trio, Robert Randolph, H.E.R., Marcus King, Sierra Hull, Kurt Rosenwinkel, Joe Bonamassa, John McLaughlin, The War On Drugs, Molly Tuttle, Del McCoury Band, and more.

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In addition to performances from world-class guitarists, attendees will be able to check out guitars and gear from the world’s top manufacturers in Guitar Center Festival Village at the adjacent Xbox Plaza and Chick Hearn Court at L.A. Live. Guitar Center will once again exhibit instruments from the company’s multi-million dollar Legends Collection of historically significant guitars, including Clapton’s “Blackie” Strat and cherry ES-335, as well as Stevie Ray Vaughan’s “Lenny” Strat.

Additionally, Guitar Center, in partnership with Eric Clapton, will unveil the 25th Anniversary Crossroads Guitar Collection–”a rare series of meticulously crafted, limited-edition guitars, based on vintage, iconic instruments that Clapton played early in his career with Cream, Blind Faith and Derek and the Dominos.” A portion of the proceeds will benefit Clapton’s Crossroads Centre at Antigua, which provides treatment and education to chemically and alcohol dependent persons and their loved ones.

Tickets for Crossroads Guitar Festival go on sale on April 21st. Only single-day tickets will be available. View the full lineup below, and for more information and ticketing details, visit the festival website.