Pearl Jam opened up their highly anticipated tour last night at Movistar Arena in Santiago, Chile, marking their first proper performance together since August 2016. Earlier this week, the Seattle rockers officially released a new single, entitled “Can’t Deny Me”, that will be featured on their forthcoming album, marking Pearl Jam’s first original release since 2013’s Lightning Bolt LP.

Pearl Jam used Tuesday night’s stage to deliver the politically-charged rock anthem for its first official live performance, dedicating it to the victims of the mass shooting at Marjory Stoneman Douglass High School in Parkland, Florida.

The band also paid tribute to Chris Cornell, Vedder’s Temple Of The Dog bandmate and Soundgarden frontman who passed away last year, with an emotional version of “Come Back” during the encore.

The career-spanning setlist also featured covers of Van Halen‘s “Eruption”, Victoria Williams‘ “Crazy Mary”, Pink Floyd‘s “Comfortably Numb”, Wayne Cochran‘s “Last Kiss”, and The Who‘s “Baba O’Riley”. You can watch fan-shot videos of Pearl Jam’s first show on tour below.

Pearl Jam – “Can’t Deny Me” – 3/13/18

[Video: Osvaldo Saez]

Pearl Jam – “Come Back” – 3/13/18

[Video: Romina Souza]

Pearl Jam – “Better Man” – 3/13/18

[Video: felipe arratia]

Pearl Jam – “Comfortably Numb” – 3/13/18

[Video: Osvaldo Faúndez]

Pearl Jam – “Baba O’Riley” – 3/13/18

[Video: frgonzal]

Following their South American tour, the band is slated to perform in Europe this summer, before they head back to North American for a series of stadium shows, dubbed the “Home Shows” in Seattle and the “Away Shows” at Boston’s Fenway Park, Chicago’s Wrigley Field and Missoula, Montana’s Washington-Grizzly Stadium. Head to the band’s website for more information on upcoming dates.

Setlist: Pearl Jam | Movistar Arena | Santiago, Chile | 3/13/18

Release, Of The Girl, Low Light, Animal, Mind Your Manners, Hail Hail, Love Boat Captain, Corduroy, Dissident, Even Flow, Present Tense, Given to Fly, Garden, The Fixer, Eruption (Van Halen), Lightning Bolt, Can’t Deny Me, Porch

E: Around The Bend, Footsteps, Come Back, Crazy Mary (Victoria Williams), Do The Evolution, Better Man, Black, Comfortably Numb (Pink Floyd), Alive

E2: Last Kiss (Wayne Cochran), Baba O’Riley (The Who), Indifference