For the first time in 21 years, Talking Heads members David ByrneTina WeymouthChris Frantz, and Jerry Harrison will appear together in the same room. The Talking Heads “reunion” will occur September 11th at the Toronto International Film Festival for the premiere of the newly remastered version of Stop Making Sense.

In celebration of the 40th anniversary of the groundbreaking concert film, Talking Heads have issued a new 4K version of Stop Making Sense, set to premiere at the Canadian film festival. Immediately following the screening, the four band members will sit for a Q&A with director Spike Lee, with whom Byrne recently worked on the film adaptation of his Broadway production American Utopia. The film and the Q&A will simulcast in select theaters around the world, with the remastered Stop Making Sense making its standalone premiere September 22nd.

Byrne, Weymouth, Frantz, and Harrison last appeared together at the 2002 Rock & Roll Hall of Fame induction ceremony. After being inducted by Anthony Kiedis (Red Hot Chili Peppers), the quartet performed a selection of hits including “Life During Wartime”, “Psycho Killer”, and “Burning Down The House”.

While all four members have not assembled in the intervening two decades, that hasn’t stopped various configurations of bandmates from playing nice. Back in March, Weymouth and Frantz dropped in on Harrison to see his current tour with former Talking Heads guitarist Adrian Belew honoring the band’s 1980 masterpiece Remain In Light. A photo the three posted backstage in Connecticut fueled reunion rumors days before the Stop Making Sense re-release was announced.

Two months after the three-quarter reunion, however, Byrne appeared on 60 Minutes where host Anderson Cooper asked him if he has thought about getting the band back together.

“No. I realized after a while that I was very happy doing the kind of wide variety of things that I was doing and the different kinds of music that I was doing,” Byrne replied. “And I thought, ‘Why should I trade in my happiness for some cash?'”

Cooper followed up, asking, “You don’t see a creative reason to do a reunion, it would just be a financial reason. And you’re not driven by that?”

“Exactly, yeah,” Byrne responded.

David Byrne on the songs that made Talking Heads famous | 60 Minutes