Will Ferrell has announced the second Best Night of Your Life, a star-studded evening of music and comedy benefitting Cancer for College on Saturday, October 21st, 2023 at the Greek Theatre in Los Angeles, CA.

Ferrell will host the charity event, which will feature of comedians Jon Stewart, Hasan Minhaj, Jo Koy, Patti Harrison, Roy Wood Jr., Rory Scovel, plus a special appearance by SmartLess with Jason Bateman, Sean Hayes, and Will Arnett. The benefit will also include a stellar musical lineup assembled by Pearl Jam‘s Mike McCready featuring Stefan Lessard (Dave Matthews Band), Beck, St. Vincent, Cindy Blackman Santana, Dogstar featuring Bret Domrose, Robert Mailhouse & Keanu Reeves, along with Jack Black and Fred Armisen who will perform as the one-time supergroup ‘Mike McCready and The Casual Acquaintances’, with additional performances by DJ White Shadow and Princess featuring Maya Rudolph and more specials guests to be announced.

Related: Will Ferrell Sits In On Cowbell At His Son’s First Concert

“Immediately upon completing our last show in 2018, I set out on a search of the cosmos,” said Will Ferrell. “The mission was to find the most incredible lineup of talent this world has ever seen. I think we can comfortably say mission accomplished. For those of you saying, ‘but Will, we’ve seen you a lot over the last five years in successful films, on popular streaming platforms and wildly funny TV appearances’, I’m here to tell you that cloning is real. Shoutout to Bill Ferrell, you did a hell of a job in my absence. My clones and I are super proud to be supporting the charity, Cancer for College. I think we can all get on board with hating cancer and the terrible things that can come with it. For 30 years, this organization has been providing need-based college scholarships, educational experiences and medical debt relief to cancer survivors. All the proceeds from the show will benefit the cause.”

“I can’t wait to rock out at Will Ferrell’s Best Night of Your Life 2!” Mike McCready added. “The first one in 2018 was an incredible experience. I’m stoked and honored to be putting together an amazing All-Star band for this event! You don’t want to miss it!”

Ferrell and McCready previously shared the stage as part of one-off supergroups at a number of Cancer for College benefits over the years, including ‘Chad Smith’s Super Mega Funktastic Jam Rock All Stars‘ alongside Chris Martin, Duff McKagan, Stefan Lessard, Josh Klinghoffer, and Brad Paisley (2018), ‘Are You There God? It’s Me, Margaret‘ featuring Chad Smith, Brandi Carlile, Josh Klinghoffer, and Stefan Lessard (2018), and ‘I Pissed My Pants’ with Chad Smith and Brandi Carlile (2014).

Presale tickets for the Best Night of Your Life featuring Will Ferrell will be available starting Wednesday, August 9th at 10 a.m. PT via the Greek Theatre and Ticketmaster. Tickets will go on sale to the general public on Friday, August 11th at 10 a.m. PT.

A limited number of BFD VVVIP Ticket Packages will be available, which include a VIP entrance, BFD dedicated lanyard, tickets within the first 12 rows, access to the VVVIP Lounge, food and beverages, and a complimentary t-shirt and signed poster.

For more information, please visit Will Ferrell’s Best Night of Your Life 2 on Ticketmaster or the Greek Theatre.

The event celebrates the 30th anniversary of Cancer for College, a nonprofit that provides need-based college scholarships and educational experiences to cancer survivors. The organization was founded in 1993 by three-time cancer survivor and double amputee Craig Pollard, Ferrell’s fraternity brother at the University of Southern California. “We are so thankful to our friend Will Ferrell and his talented group of friends for supporting our cause,” said Pollard. “The results of this event will provide several hundred cancer survivors an opportunity to attend college and lower their medical debt.”

Will Ferrell’s Best Night of Your Life 2 is executive produced and created by Cocolittle Media. “Producing once in a lifetime music & comedy events in support of Will Ferrell’s charity, Cancer for College, couldn’t be any more rewarding,” said Laura Glass, Executive Producer and Founder at Cocolittle Media. “Playing a small role which furthers the lives of young cancer survivors is just about as good as it gets.”

Will Ferrell’s Best Night of Your Life 2 Announcement Video