Mempho Music Festival will return to the Radians Amphitheater in fall 2022 with headliners The Black KeysWidespread Panic (two nights), Wilco, and Jason Isbell and The 400 Unit. The urban festival will take place September 30th through October 2nd at the Memphis Botanic Garden.

Also on tap for the fifth installment of Mempho are Portugal. The ManTank And The BangasFantastic NegritoBobby RushAllison RissellCelisseBig Ass TruckFuturebirdsDelvon Lamarr Organ TrioBette SmithAdia VictoriaAmy Lavere, and Elizabeth King. Since debuting in 2017, Mempho continues to grow, as evidenced by the event’s ability to sell out all three days at its new home of the Radians Amphitheater last year, with plans to increase capacity going forward.

Related: Widespread Panic Welcomes Billy Strings For Extended Sit-In At Mempho Festival [Videos]

General admission and VIP tickets for Mempho Music Festival 2022 are now on sale at tier two pricing for $195 and $660 respectively. This year will once again see the event partner with St. Jude Children’s Research Hospital as a beneficiary. The Memphis-based charity provides treatment to children diagnosed with cancer at no cost to their families.

In addition to three days and nights of music, Mempho Music Festival seeks to highlight the cultural landscape of Southwestern Tennessee. Organizers will curate the event to further explore the city’s rich musical history, continuing the tradition from past years.